Overall I can't really answer these questions, because it voils down to "what do you want to do?"

This one, though:

Do I go urban fantasy? How do I distinguish it from my current urban fantasy?

If you do go with another urban fantasy, I recommend aiming for a different tone. I imaging C:tL is pretty dramatic and angsty; you could run something that's much more overtly horror-themed, or light-hearted and silly, or whatever. Setting a clear tone from the start can help keep the game from falling into the same patterns as the previous one, while you get momentum on the plots and such.